5-MTHF - 60 capsules

Formula Overview

5-MTHF is a single-ingredient capsule providing the active 5-methyltetrahydrofolate form of folate as Quatrefolic. The active form supports steady folate availability without depending on individual conversion capacity from folic acid.

A note from Evey

Folate is one of the most important methyl donors your body uses, which means it sits upstream of DNA synthesis, neurotransmitter production, and how the body handles homocysteine. 5-MTHF is the active circulating form of folate, the version your tissues actually use. Many people convert ordinary folic acid into 5-MTHF less efficiently because of common variations in the MTHFR gene, and a 5-MTHF supplement bypasses that conversion step entirely.

What sets this formula apart is the use of Quatrefolic, a patented and well-absorbed crystalline form of 5-MTHF that is more stable than older folate forms. The capsule is also clean and uncluttered, which makes it easy to layer on top of a multivitamin or to pair with B12 when methylation support is the goal.

This is a quiet nutrition foundational, the kind that fills a gap rather than makes a statement. Folate is in dark leafy greens, beans, and liver, and a real-food first approach is always the place to start. The supplement fills the gap that diet alone may not close, particularly for people with MTHFR genetics, those on long-term medications that influence folate status, or anyone planning a pregnancy.

I generally suggest one capsule with food, on most days, alongside a green vegetable habit.

Form: Capsule, 60 count

Disclosure: Evey Andersen, FNP-C, MSN, APNP, CISSN, is the owner of Green Medicine of Wisconsin and recommends this product based on clinical experience.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.